Literally means to know that the kidney damage
caused by diabetes, what is the reason? Diabetes and kidney how kind of
relationship? Play a key role, perhaps even what are the initiating factor in
diabetic nephropathy, it?
Hyperglycemia
Diabetic nephropathy is closely related to high blood sugar, poor blood sugar control can accelerate the occurrence and development of diabetic nephropathy, glycemic control can significantly slow down its development. Hyperglycemia and advanced glycation end products generate increased cause mesangial cell proliferation, increased extracellular matrix, mesangial expansion, glomerular basement membrane thickening.
(1) hyperglycemia, glomerular hyperperfusion, hyperfiltration state, across the capillary wall pressure increased, so that the expansion of mesangial cells, epithelial cell foot process fusion and produce dense droplets, glomerular epithelial cells from the basal membrane shedding.
(2) increased glomerular basement membrane collagen type Ⅳ messenger sugar, nucleic acid, basement membrane thickening, and ultimately the formation of diffuse mesangial nodular lesions, the occurrence of glomerular sclerosis.
(3) In the case of increased pressure, protein filtration increase, can also be deposited in the mesangial area and glomerular basement membrane, promoting stromal proliferation, creating a vicious cycle, and can cause nodular and diffuse glomerulosclerosis .
Genetic factors
Why in diabetic nephropathy? The majority of patients with diabetes eventually kidney disease does not occur, but the same, there may be some good long-term glycemic control in patients with diabetic nephropathy. Glucose transporter protein -1 (GLUT1) is the major glucose transporter in mesangial cells.
Recent studies have found that among individuals with diabetes mesangial cell GLUT1 menu up and differences in the regulation is one of the factors in some patients susceptible to kidney damage. And diabetic nephropathy also showed family aggregation, and some family history of hypertension in diabetic patients, the incidence of diabetic nephropathy was significantly higher than in patients without hypertension, family history. In addition, the incidence of diabetic nephropathy between the different races there are also differences. This show of diabetic nephropathy and genetic factors.
Hyperglycemia
Diabetic nephropathy is closely related to high blood sugar, poor blood sugar control can accelerate the occurrence and development of diabetic nephropathy, glycemic control can significantly slow down its development. Hyperglycemia and advanced glycation end products generate increased cause mesangial cell proliferation, increased extracellular matrix, mesangial expansion, glomerular basement membrane thickening.
(1) hyperglycemia, glomerular hyperperfusion, hyperfiltration state, across the capillary wall pressure increased, so that the expansion of mesangial cells, epithelial cell foot process fusion and produce dense droplets, glomerular epithelial cells from the basal membrane shedding.
(2) increased glomerular basement membrane collagen type Ⅳ messenger sugar, nucleic acid, basement membrane thickening, and ultimately the formation of diffuse mesangial nodular lesions, the occurrence of glomerular sclerosis.
(3) In the case of increased pressure, protein filtration increase, can also be deposited in the mesangial area and glomerular basement membrane, promoting stromal proliferation, creating a vicious cycle, and can cause nodular and diffuse glomerulosclerosis .
Genetic factors
Why in diabetic nephropathy? The majority of patients with diabetes eventually kidney disease does not occur, but the same, there may be some good long-term glycemic control in patients with diabetic nephropathy. Glucose transporter protein -1 (GLUT1) is the major glucose transporter in mesangial cells.
Recent studies have found that among individuals with diabetes mesangial cell GLUT1 menu up and differences in the regulation is one of the factors in some patients susceptible to kidney damage. And diabetic nephropathy also showed family aggregation, and some family history of hypertension in diabetic patients, the incidence of diabetic nephropathy was significantly higher than in patients without hypertension, family history. In addition, the incidence of diabetic nephropathy between the different races there are also differences. This show of diabetic nephropathy and genetic factors.
