Polycystic kidney disease patients after a longer duration of disease,
clinical examination, there will be fluctuations in creatinine and creatinine
significantly increased, even serum creatinine values above the normal range,
which means that the development of renal insufficiency or uremia. These mainly
to higher than normal for serum creatinine, urine creatinine is less than
normal.
This is increasing due to cysts within the kidneys of patients with polycystic kidney and oppression around the renal tissue, resulting in the destruction of the nephron, advanced polycystic kidney disease in patients with kidney volume far exceeds the normal organization microscopic examination will not see any normal kidney units.
Kidney by a violation of these cysts after the first impaired renal inherent cell phenotypic transition, the formation of pathological changes, to stimulate kidney fibroblasts into myofibroblasts, but also violated and stimulate the inherent normal kidney tissue, of the same disease, thus forming a kidney from point to plane, from the local to the overall expansion of the excitation spread process, to enter the device matter injury period (ie, renal injury period), due to kidney to continue to cause injury, the function of the excretion of waste reduced, causing the aggregation of creatinine and other toxins in the body, which appears within the blood creatinine, urea nitrogen, urine creatinine decreased kidney filtration rate decreased. At the same time patients will have other physical symptoms of high blood pressure, a high degree of swelling.
This is increasing due to cysts within the kidneys of patients with polycystic kidney and oppression around the renal tissue, resulting in the destruction of the nephron, advanced polycystic kidney disease in patients with kidney volume far exceeds the normal organization microscopic examination will not see any normal kidney units.
Kidney by a violation of these cysts after the first impaired renal inherent cell phenotypic transition, the formation of pathological changes, to stimulate kidney fibroblasts into myofibroblasts, but also violated and stimulate the inherent normal kidney tissue, of the same disease, thus forming a kidney from point to plane, from the local to the overall expansion of the excitation spread process, to enter the device matter injury period (ie, renal injury period), due to kidney to continue to cause injury, the function of the excretion of waste reduced, causing the aggregation of creatinine and other toxins in the body, which appears within the blood creatinine, urea nitrogen, urine creatinine decreased kidney filtration rate decreased. At the same time patients will have other physical symptoms of high blood pressure, a high degree of swelling.
