Nephrotic syndrome, in fact, it is not a nephropathy, but with the same
clinical symptoms collectively referred to as a glomerular disease. These same
clinical symptoms, ie patients with nephrotic syndrome is often said that the
"three high and one low": massive proteinuria, edema, hyperlipidemia, and
hypoproteinemia. The occurrence of massive proteinuria can directly lead to
kidney patients produce edema, hyperlipidemia, and hypoproteinemia. Massive
proteinuria is the basic characteristics of the nephrotic syndrome, is also a
diagnostic sign of symptoms of nephrotic syndrome.
In the end nephrotic syndrome in patients with massive proteinuria is how to generate it? This can be explained from the following aspects.
Nephrotic syndrome in a large number of proteins in the urine of patients is mainly derived from their blood. Under normal circumstances, renal comprehensive vast majority of protein in the blood of the patients does not appear in the urine, especially macromolecular protein and the negatively charged protein does not appear, this is because the human kidney glomerular there filtration barrier and hinder the filter out of the protein.
Human kidney glomerular filtration barrier consists of glomerular capillary endothelial cells, basement membrane and glomerular capsule of visceral epithelial cells (shown). When cold, tired, weak incentives role in disease resistance (ie, clinical said low immunity) crowd, very easy to make such a crowd glomerular capillary endothelial cells, visceral epithelial cells and basement membrane, etc. kidney tissue fibrosis, so damage to the kidneys normally hinder protein filtration barrier structure, resulting in glomerular filtration lesions occur. Occurrence of fibrosis in the kidney, the glomerular filtration barrier filtration aperture large, large amounts of protein from the glomerular basement membrane filtration into the urine.
email:ckdsite@hotmail.com
In the end nephrotic syndrome in patients with massive proteinuria is how to generate it? This can be explained from the following aspects.
Nephrotic syndrome in a large number of proteins in the urine of patients is mainly derived from their blood. Under normal circumstances, renal comprehensive vast majority of protein in the blood of the patients does not appear in the urine, especially macromolecular protein and the negatively charged protein does not appear, this is because the human kidney glomerular there filtration barrier and hinder the filter out of the protein.
Human kidney glomerular filtration barrier consists of glomerular capillary endothelial cells, basement membrane and glomerular capsule of visceral epithelial cells (shown). When cold, tired, weak incentives role in disease resistance (ie, clinical said low immunity) crowd, very easy to make such a crowd glomerular capillary endothelial cells, visceral epithelial cells and basement membrane, etc. kidney tissue fibrosis, so damage to the kidneys normally hinder protein filtration barrier structure, resulting in glomerular filtration lesions occur. Occurrence of fibrosis in the kidney, the glomerular filtration barrier filtration aperture large, large amounts of protein from the glomerular basement membrane filtration into the urine.
email:ckdsite@hotmail.com
