Thursday 5 July 2012

Nephrotic syndrome, a high degree of swelling

(1), plasma colloid osmotic pressure: The blood vessels inside and outside the exchange of body fluids is subject to both sides of the osmotic pressure regulation. Osmotic pressure crystal osmotic pressure and colloid osmotic pressure,
The former from the crystalline material (electrolyte), because it can be freely through the capillary wall, so the small blood vessels inside and outside the exchange of body fluids; the latter mainly from proteins (mainly albumin), it can not pass through freely capillary wall, and thus is a major factor in the blood vessels inside and outside the exchange of body fluids. Nephrotic syndrome due to a large number of plasma proteins from the urine is lost, causing hypoproteinemia, resulting in lower plasma colloid osmotic pressure, when the normal 3.3 ~ 4kPa to 0.8 ~ 1.1kPa, intravascular water to the hypertonic interstitial fluid move, and edema.
(2) effective hypovolemia: the relocation of plasma water to make effective hypovolemia, which led to the following changes in the body: increase the capacity of receptors to the anti-diuretic hormone (ADH), so that the tubular reabsorption of water; excited kidney hormone - angiotensin - aldosterone system, resulting in secondary aldosteronism, tubular reabsorption of sodium increased; inhibit the generation of the natriuretic factor to reduce the renal natriuresis. Such a body of water, sodium retention, further exacerbating the edema.
These two factors resulted in a high degree of swelling of nephrotic syndrome.
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